Agilent
6470 Triple Quadrupole LC-MS
Provisional entry — research in progress
This page was generated automatically from cited public sources and hasn't completed the full research pass yet. Every specification shown carries its source; more detail is added as research completes.
How it works
The Agilent 6470 uses a triple quadrupole mass analyzer. In triple quadrupole operation, the first quadrupole (Q1) selects precursor ions, the second quadrupole (Q2) acts as a collision cell to fragment those ions, and the third quadrupole (Q3) selects specific product ions for detection. The system features the Agilent Jet Stream (AJS) source, which enhances ion formation and enables detection limits down to the sub-femtogram level. The instrument includes VacShield technology, which allows ion injector capillary maintenance without the need for venting the system. The Agilent 6470 supports triggered multiple reaction monitoring (tMRM), which combines MRM quantitation with the generation of product ion spectra for compound screening and confirmation. The instrument is 30% smaller than previous designs.[1][4]
Applications
The Agilent 6470 triple quadrupole LC-MS is applied to quantitative analysis in food testing, environmental analysis, drug development, and clinical research. The system is used for trace-level quantitation in complex matrices such as biological fluids, food extracts, and environmental samples. The triggered MRM capability supports both quantitative screening and confirmatory analysis by generating product ion spectra for library searching.[5][4]
What do the numbers mean?
Power & electrical1
- System includes
- Agilent G6470A QQQ Triple Quadrupole LC/MS, Agilent/Parker Balston NitroFlowLab-K727 Nitrogen Generator, Agilent G6011A Quiet Cover MS for MS40+ Rotary Vane Pump Rough pump PC with Data[4]
Vacuum & pumping1
- Flex Pump (G7104A) with Degasser, MCT (G7116B) with Thermostat, MultiSampler (G7167A) & Solvent TrayComputer Loaded with MassHunter and workstation.[2]
Optics & imaging2
Dimensions & facilities3
Configuration & options14
- Features
- VacShield technology, triggered MRM, built-in technical controls, procedural controls[2]
Vintage & configurations
- 2015-07-06Presentation/publication date[1]
A source dated 6 Jul 2015 introduces the 6470 triple quadrupole LC-MS as new.
- 2015introduced at ASMS 2015[1]
The Agilent 6470 Triple Quadrupole LC-MS was introduced at the American Society for Mass Spectrometry (ASMS) conference in 2015.
- 2015-07-06ASMS 2015 introduction[1]
The 6470 triple quadrupole LC-MS was introduced in July 2015.
What replaced it?
Alternatives
Tools documented as functional equivalents — same process step and wafer size, from a different manufacturer. Each equivalence cites its source.
- SCIEX API 3000— Same function class: Precision Optics, nullCompare in depthsource[3]
What does it need to run?
Site utility requirements, footprint, and infrastructure needed to install and operate this tool. Sourced from public records.
- ConfigurationFlex Pump (G7104A) with Degasser, MCT (G7116B) with Thermostat, MultiSampler (G7167A) & Solvent TrayComputer Loaded with MassHunter and workstation.[2]
- System includesAgilent G6470A QQQ Triple Quadrupole LC/MS, Agilent/Parker Balston NitroFlowLab-K727 Nitrogen Generator, Agilent G6011A Quiet Cover MS for MS40+ Rotary Vane Pump Rough pump PC with Data[4]
Where are the manuals?
Generated from public-source data on file. Enter your email to access — nothing is published; details are routed privately.
Not publicly documented
Field notes
No research found yet — worked with this tool? Share what you know.
Frequently asked questions
When was the Agilent 6470 introduced?
The Agilent 6470 Triple Quadrupole LC-MS was introduced at the American Society for Mass Spectrometry (ASMS) conference in 2015.[1]
What ion source technology does the Agilent 6470 use?
The Agilent 6470 uses the Agilent Jet Stream (AJS) source, which enables detection limits down to the sub-femtogram level.[4]
What feature allows capillary maintenance without venting?
The Agilent 6470 incorporates VacShield technology, which permits ion injector capillary maintenance without the need for venting the system.[4]
What is the purpose of triggered MRM (tMRM)?
Triggered MRM combines rapid and sensitive multiple reaction monitoring quantitation with the generation of product ion spectra for library searching, compound screening, and confirmation.[4]
What regulatory compliance features are built into the Agilent 6470?
The Agilent 6470 includes built-in technical and procedural controls to facilitate compliance with regulations such as US FDA 21 CFR Part 11 and EU Annex 11.[4]
Not publicly documented
The following facts about the 6470 Triple Quadrupole LC-MS are absent from this record as of this revision. First-hand knowledge or a citation closes a gap; every submission is reviewed before publication.
No publicly documented variants, configuration options, or revision breakpoints of the 6470 Triple Quadrupole LC-MS are on record.
Answerable by: an OEM product catalog or an engineer who ordered or specified the tool
The control-system platform and OS era of the 6470 Triple Quadrupole LC-MS are not on record.
Answerable by: an engineer who operated it or OEM installation records
No publicly documented failure modes or field errata for the 6470 Triple Quadrupole LC-MS are on record.
Answerable by: a field service engineer, process engineer, or maintenance technician
The process node or technology generation of the 6470 Triple Quadrupole LC-MS is not on record.
Answerable by: an OEM datasheet or a fab qualification report
No publicly documented compatible parts, consumables, or accessories for the 6470 Triple Quadrupole LC-MS are on record.
Answerable by: an OEM parts catalog or a service engineer
No research found yet — worked with this tool? Share what you know.
Sources & citations
Sources (6)Every fact above is drawn from these public sources
- [1]bioanalysis-zone.com — bioanalysis-zone.combioanalysis-zone.com
- [2]inventory listing
- [3]spectralabsci.com — spectralabsci.comspectralabsci.com
- [4]gmi-inc.com — gmi-inc.comgmi-inc.com
- [5]The Agilent 6470 Triple Quadrupole LC-MS System (Agilent) - Bioanalysis Zone — bioanalysis-zone.combioanalysis-zone.com
- [6]Agilent 6470 Triple Quadrupole LC/MS Mass Spectr | QuestPair — questpair.comquestpair.com
Last updated Oct 8, 2026.
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